Differential Patterns of Glucose-Induced Electrical Activity and Intracellular Calcium Responses in Single Mouse and Rat Pancreatic Islets

摘要

Although isolated rat islets are widely used to study in vitro insulin secretion and the underlying metabolic and ionic processes, knowledge on the properties of glucose-induced electrical activity (GIEA), a key step in glucose-response coupling, has been gathered almost exclusively form microdissected mouse islets. Using a modified intracellular recording technique, we have now compared the patterns of GIEA in collagenase-sio- lated rat and mouse islets.