The Constitutive Secretory Pathway Is a Major Route for Islekt Amyloid Polypeptide Secretion in Neonatal but Not Adult Rat Islet Cells

摘要

Islet amyloid polyeptide (IAPP or amylin) is a normal secretory product of the pancreatic β-cell that is cose- creted with insulin and is the major constituent of islet amyloid deposits in individuals with type 2 diabetes or insulinomas. We have previously reported that glucose stimulates IAPP, but not insulin secretion, from neona- tal rat β-cells when regulated secretion is prevented by use of calcium-free media, suggesting that IAPP secre- tion occurs via a constitutive secretory pathway.