Brief Genetics Report: Analysis of the Mouse CD30 Gene A Candidate for the NOD Mosue Type 1 Diabetes Locus Idd9.2

摘要

Members of the tumor necrosis factor receptor superfam- ily play an important role in the initiation, expansion, and termination of an immune response. It has recently been demonstrated that one member of this family, CD30, plays a central role in maintaining peripheral tolerance by con- trolling the expansion of autoreactive CD8~+ T-cells. In the present study, Cd30 was mapped to a 5.6-cM interval on chromosome 4 containing the type 1 diabetes susceptibil- ity locus Idd9.2.