Original Articles: Molecular Mode of Inhibition of Glycogenolysis In Rat Liver by the Dihydropyridine Derivative, BAY R3401

摘要

The racemic prodrug BAY R3401 suppresses hepatic glycogenolysis. BAY W1807, the active metabolite of BAY R3401, inhibits muscle glycogen phosphorylase αand b. We investigate whether BAY R3401 reduce hepatic Glycogenolysis by allosteric inhibition or by phosphatase- Catlayzed inactivation of physorylase. In gel-filtered Liver extracts, racemic BAY U6751 (containing active BAY W1807) was tested for inhibition of phosphorylase In the glycogenolytic (in which only phosphorylase αis ActivE) and glycogen-synthetic (for the evaluation of α:b Ratios) directions.