Brief Genetics Report: The K121Q Variant of the Human PC-1 Gene Is Not Associated With Insulin Resistance or Type 2 Diabetes Among Danish Caucasians

摘要

The human plasma-cell membrane differentiation anti- gen-1 (PC-1) has been shown to inhibit insulin receptor tyrosine kinase activity. Recently, a K121Q polymor- phism in the human PC-1 gene was found in a Sicilian population and was shown to be strongly associated with insulin resistance. The objectives for the present investigation were to examine in the Danish Caucasian population whether the K121Q variant was associated with type 2 diabetes or, in glucose-tolerant subjects, with impaired whole-body insulin sensitivity.