Type 2 Diabetes-Like Hyperglycemia in a Backcross Model of NZO and SJL Mice Characterization of a Susceptibility Locus on Chromosome 4 and Its Relation With Obesity

摘要

A backcross model of New Zealand obese mice (NZO) with the lean, atherosclerosis-resistant SJL strain was established to locate genes responsible for obesity, insulin resistance, and type 2 diabetes-like hypergly- cemia. In male NZO×F1 backcross mice, a major sus- ceptibility locus for the development of hyperglycemia and hypoinsulinemia (Nidd/SJL) was identified on chro- mosome 4 between the markers D4Mit278 and D4Mit232, 10-28 cM distal of the previously described Nidd1 locus.