Genetic variation in the peroxisome proliferator-activated receptor-γ2 gene(Pro12Ala) affects metabolic responses to weight loss and subsequent weight regain

摘要

This study determined the effects of the peroxisome proliferator-activated receptor(PPAR)-γ2 Pro12Ala variant on body composition and metabolism and the magnitude of weight regain in 70 postmenopausal women(BMI 25-40 kg/m~2)who completed 6 months of a hypocaloric diet. At baseline, BMI, percent body fat, intra-abdominal and subcutaneous abdominal fat areas, resting metabolic rate, substrate oxidation, and post- prandial glucose and insulin responses were not differ- ent between genotypes(Pro/Pro = 56, Pro/Ala and Ala/Ala = 14).