Low acute insulin secretory responses in adult offspring of people with early onset type 2 diabetes

摘要

The offspring of Pima Indians with early onset type 2 diabetes are at high risk for developing diabetes at an early age. This risk is greater among those whose moth- ers were diabetic during pregnancy. To define he met- abolic abnormalities predisposing individuals in these high-risk groups to diabetes, we conducted a series of studies to measure insulin secretion and insulin action in healthy adult Pima Indians.