Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation

摘要

Studies in Zucker diabetic fatty rats have led to the concept that chronically elevated free fatty acid(FFA) levels can cause apoptosis of tirglyceride-laden pancre- aticβ-cells as a result of formation of ceramides, which induce nitric oxide(NO)-dependent cell dealth. This "lipotoxicity" hypothesis could explain develop- Ment of type 2 diabetes in obesity. The present study Examines whether prolonged exposure to FFA affects Outcome is related to the occurrence of triglyceride Accumulation.