PKCδ Activation: a divergence point in the signaling of insulin and IGF-1-induced proliferation of skin kerationcytes

摘要

Insulin and insulin-like growth factor-1(IGF-1)are members of the family of the insulin family of growth factors, which activate similar cellular downstream pathways. In this study, we analyzed the effects of insulin and IGF-1 on the proliferation of murine skin keratinocytes in an attempt to determine whether these hormones trigger the same signaling pathways. Increasing doses of insulin and IGF-1 promote ker- Atinocyte proliferation in an additive manner.