首页> 外文期刊>Diabetes >Diabetic Patients Without Vascular Complications Display Enhanced Basal Platelet Activation and Decreased Antioxidant Status.
【24h】

Diabetic Patients Without Vascular Complications Display Enhanced Basal Platelet Activation and Decreased Antioxidant Status.

机译:没有血管并发症的糖尿病患者表现出增强的基础血小板活化和降低的抗氧化状态。

获取原文
获取原文并翻译 | 示例
       

摘要

Vascular complications are the leading causes of morbidity and mortality in diabetic patients. The contribution of platelets to thromboembolic complications is well documented, but their involvement in the initiation of the atherosclerotic process is of rising interest. Thus, the aim of the present study was to evaluate basal arachidonic acid metabolism in relation to the redox status of platelets in both type 1 and type 2 diabetic patients, in the absence of vascular complications, as compared with respective control subjects. For the first time, we show that basal thromboxane B(2), the stable catabolite of thromboxane A(2), significantly increased in resting platelets from both type 1 and type 2 diabetic patients (58 and 88%, respectively), whereas platelet malondialdehyde level was only higher in platelets from type 2 diabetic subjects (67%). On the other hand, both vitamin E levels and cytosolic glutathione peroxidase activities were significantly lower in platelets from diabetic patients as compared with respective control subjects. We conclude that platelet hyperactivation was detectable in well-controlled diabetic patients without complications. This abnormality was associated with increased oxidative stress and impaired antioxidant defense in particular in type 2 diabetic patients. These alterations contribute to the increased risk for occurrence of vascular diseases in such patients.
机译:血管并发症是糖尿病患者发病和死亡的主要原因。血小板对血栓栓塞性并发症的贡献已有充分的文献记载,但是它们参与动脉粥样硬化过程的启动引起了越来越多的兴趣。因此,本研究的目的是评估在没有血管并发症的情况下,与各对照组相比,基础型花生四烯酸代谢与1型和2型糖尿病患者血小板的氧化还原状态有关。首次,我们显示基础血栓素B(2),即血栓素A(2)的稳定分解代谢物,在1型和2型糖尿病患者的静息血小板中均显着增加(分别为58%和88%),而血小板丙二醛水平仅在2型糖尿病受试者的血小板中更高(67%)。另一方面,与相应的对照组相比,糖尿病患者血小板中的维生素E水平和胞质谷胱甘肽过氧化物酶活性均显着降低。我们得出结论,在控制良好的糖尿病患者中可检测到血小板过度活化而无并发症。这种异常与氧化应激增加和抗氧化防御能力受损有关,特别是在2型糖尿病患者中。这些改变导致此类患者发生血管疾病的风险增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号