Mortality Risk in Long-Standing Type 1 Diabetes: Hope and Concern

摘要

In this issue of Diabetes, Secrest et al. (1) explore the long-term cause-specific mortality experience of youth diagnosed with type 1 diabetes (<18 years of age over the 15-year period from 1965 to 1979) to determine if improvements in mortality have occurred over time. The findings are at the same time both hopeful and concerning. The results among these youth (now middle-aged adults) come from the Alleghany County Type 1 Diabetes Registry established in the mid-1970s. One of the first U.S. registries of type 1 diabetic subjects, it was one of the archetypical registries that forged the international collaboration linking registries in the U.S., Europe, and Asia (2). The report by Secrest et al. focuses on over 30 years of follow-up among 1,043 subjects with diabetes from the original 1,075 identified in the county. This represents