In Silico Docking Studies of Conventional and Non Conventional Antibiotics with Staphylococcus aureus

摘要

In the present study a comparative insilico docking studies of Actagardine (non conventional) and Cefuroxime (conventional) with three toxins of Staphylococcus aureus (exfoliative toxins A, B and Panton-Valentine leukocidin) was carried out. These toxins are responsible for skin infections caused by this pathogen. Actagardine gave negative binding energy with all these three toxins of Staphylococcus aureus. Although the binding energies of Actagardine are less than that with Cefuroxime, due to the characteristic of antimicrobial peptides these results can be considered significant. Hence, further work can be done to develop Actagardine as a non conventional drug against Staphylococcus aureus.