Editorial: HBOC and high-risk screening: up-to-date

摘要

Research on breast cancer risk revealed that 5–10% of breast cancer patients are genetically predisposed to cancers [1]. More than 25?years have passed since BRCA1 was identified and cloned [2, 3]. BRCA 1 and BRCA 2 are well-known sus- ceptibility genes for breast cancer, which are also associated with ovarian and pancreatic cancers. Recent advancement in the mechanism of hereditary breast cancer has changed the clinical approach to patients and families who are considered “high risk” for breast cancer. Genetic testing is becoming a feasible option to accurately estimate their own risk and to optimize screening/surveillance strategy.