Infiltration of CD1a-positive dendritic cells in advanced laryngeal cancer correlates with unfavorable outcomes post-laryngectomy

摘要

The prognosis of advanced laryngeal cancer is unfavorable despite advances in multidisciplinary therapy. Dendritic cells (DCs) play a central role in antitumor immunity. Tumor-infiltrating CD1a DCs have been reported to be associated with clinical outcomes in carcinomas of various organs, but the clinical impact of CD1a DCs in laryngeal cancer remains to be unequivocally established. We retrospectively analyzed the cases of 57 patients with Stage III or IV laryngeal cancer who underwent a total laryngectomy. Immunohistochemistry detection of CD1a, S100 and CD8 was performed on representative resected specimens. CD1a DCs, S100 DCs and CD8 cytotoxic T-lymphocytes (CTLs) were evaluated, and the cases divided into high and low groups according to the cut-off of the median values for each of these 3 parameters. Compared to the CD1a-low group, the CD1a-high group had more advanced cases and showed significantly worse disease-specific survival (DSS) (P?=?0.008) and overall survival (OS) (P?=?0.032). The analyses of S100 DCs and CD8 CTLs revealed no significant impact on clinical outcomes. However, multivariate analysis revealed that infiltration of CD1a DCs was an independent unfavorable prognostic factor for both DSS (P?=?0.009) and OS (P?=?0.013). Our results demonstrated that the infiltration of CD1a DCs was associated with unfavorable clinical outcomes in patients with advanced laryngeal cancer who underwent a total laryngectomy as the initial treatment.