Ameliorative impact of taurine on oxidative damage induced by Ipomoea carnea toxicity in wistar male rats through modulation of oxidative stress markers, apoptotic and Nrf2 pathway

摘要

ObjectivesThe adverse deleterious influences ofIpomoea carneaon brain tissue and Taurine's relative ability to prevent this neurotoxicity have been examined.MethodsWe utilized sixty Wistar male rats weighing 1752?g. The rats were allotted into 4 groups of fifteen each: The control group got saline i.p. daily for eight weeks; the Ipomoea carnea extract (ICE) group received ICE (15?mg/kg b.w./day) orally for eight weeks. Taurine-treated rats, in which rats were administered Taurine (200?mg·kg?1, i.p./Day) for 2?months. Taurine?+?ICE group in which rats were supplemented with (200?mg·kg?1, i.p. Taurine?+?ICE 15?mg/kg b.w./day orally) for 2?months.ResultThe findings indicated that Ipomoea persuaded an increase in lipid peroxidation markers as well as a disruption in antioxidant homeostasis, along with brain and serum cholinesterase (AChE) elevated levels, tumor necrosis factor (TNF), total creatine phosphokinase (CPK), creatine phosphokinase isoenzymes BB (CPK-BB), and lactate dehydrogenase (LDH). A considerable drop (P?