PREPARATION AND CHARACTERIZATION OF Fe3O4@SiO2@L-VALINE NANOPARTICLES AS AN EFFECTIVE AND NOVEL NANOCATALYST FOR THE SYNTHESIS OF PERIMIDINE DERIVATIVE UNDER MILD CONDITIONS

摘要

We presented an eco-friendly procedure for effective and fast preparation of biologically active substituted pyrimidine ligand through a condensation reaction of 1,8-diaminonaphthalene and 2-methoxy-benzaldehyde with Fe 3 O 4 @SiO 2 @L-valine magnetic nanoparticles (MNPs) as a new recyclable catalyst. In this experiment, we aim to increase reaction efficiency for the synthesis of 2-(2-methoxyphenyl)-2,3-dihydro-1H-perimidine ligand. Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), Energy dispersive X-ray spectrometer (EDXA), scanning electron microscopy (SEM), and vibrating sample magnetometry (VSM) were employed to characterize the catalyst. Findings demonstrated that synthesized nanocatalyst is superparamagnetic with a dimension range of 15-30 nm. The catalyst was readily recycled using an external magnet and could be recovered several times without considerable reduction in its catalytic performance. Furthermore, the metal complexes were produced from 2-(2-methoxyphenyl)-2,3-dihydro-1H-perimidine ligand. Antibacterial activities of ligand and its metal complexes were studied against G( ) and G(-) bacteria strains by disc diffusion technique. Results showed that metal complexes had better biological activities compared to parent ligands. Among the synthesized compounds, the best antibacterial activity was observed by Cu complex.