6-Bromo-2'-(2-chlorobenzylidene)nicotinohydrazide and 6-Bromo-2'-(3-bromo-5-chloro-2-hydroxybenzylidene)nicotinohydrazide Methanol Solvate: Synthesis, Characterization, Crystal Structures and Antimicrobial Activities

摘要

Two newly synthesized nicotinohydrazones, 6-bromo - 2'-(2-chlorobenzylidene)nicotinohydrazide ( 1 ) and 6-bromo - 2'-(3-bromo-5-chloro-2-hydroxybenzylidene)nicotinohydrazide methanol solvate ( 2 ), have been obtained and structurally characterized by spectroscopic method and single crystal X-ray determination. The molecules in both compounds are in E configuration regarding to the azomethine groups. The molecules of compound 1 are linked via hydrogen bonds of N?H???O, generating one dimensional chains running along the c -axis direction. The hydrazone molecules of compound 2 are linked by methanol molecules via hydrogen bonds of N?H???O and O?H???N, generating dimers. The in vitro antimicrobial activities of these compounds indicate that they are interesting antibacterial agents.