Primary ovarian insufficiency (POI) is defined as a significant reduction of the follicle pool and induction of amenorrhea before the age of 40 (Nelson, 2009), associated with a decreased level of estrogen and hypergonadotropic state in the blood. Since POI patients have few follicles, it is difficult to obtain human oocytes to decipher this disease. In mammalian ovary, granulosa cells establish direct communication with oocytes and modulate transcription and chromatin remodeling of the oocyte (De La Fuente and Eppig, 2001). However, the whole-genomic DNA methylation profile of human granulosa cells and the potential clinical insights are absent.
展开▼
机译：原发性卵巢不足（POI）被定义为卵泡池的显着减少，并且在40岁（Nelson，2009）之前的卵泡池和闭合症的诱导，与血液中的雌激素和超高速升压状态下降相关。 由于POI患者卵泡很少，因此难以获得人卵母细胞来破译这种疾病。 在哺乳动物卵巢中，颗粒细胞与卵母细胞的直接沟通，调节卵母细胞的转录和染色质重塑（de la fuente和Eppig，2001）。 然而，人颗粒细胞的全基因组DNA甲基化谱和潜在的临床洞察不存在。
展开▼
