Combinatorial genetics methods for discovering high-order regulatory combinations and engineering genetic drivers for neural differentiation

摘要

Diving into thesearch foreffectivecell differentiation factors:Researchersarestillstriving to find better therapeutics to revert or slowdown the progression of neurological disorders such as Parkinson’s disease, Alzheimer’s disease,and Huntington’s disease. These disordersaretheresult of neuronalcell death in different parts ofthe brain. Medications or treatments used to relievethesymptoms in patients have not beenwell established. They do not recover the damaged neuraltissuesand can result in unwanted sideeffects. Therefore,an increasing number ofstudies look to stemcellsasa promising therapeutic, because oftheir self-renewalcapabilitiesand flexibility of differentiation into desired celllineages for engraftment into the patient to recover thelost neuraltissues. However, beforestemcellscan beclinically used in treating neurological disorders, therearestillareas that requirea better understanding to unlock their full potential.