Therapeutic Options for Coronavirus Disease 2019 (COVID-19) - Modulation of Type I Interferon Response as a Promising Strategy?

摘要

Since December 2019, China has been experiencing an outbreak of COVID-19, caused by severeacute respiratory syndrome coronavirus 2 (SARS-CoV-2). This disease has spread rapidly tomultiple countries and become responsible for the greatest pandemic of the century, as declaredby the WHO. The clinical spectrum encompasses asymptomatic infection, mild upper respiratorytract illness, and severe viral pneumonia with respiratory failure (1), with a high mortality estimatedaround 2% in diagnosed patients (2). Identification of an efficient therapy has now become amajor health emergency to avoid health system saturation, especially the medical capabilities ofrespiratory resuscitation. A large number of clinical trials is currently underway, but no treatmentof proven efficacy is known at present. The lack of data from large-scale clinical trials involvingCOVID-19 patients hampers reliable statistical analyses. In this context of emergency, an in-depthanalysis of published preliminary data may help to improve our understanding of disease outcomesand shed light upon potentially efficacious treatment strategies.