Organ Preservation Solutions in Transplantation: A Literature Review

摘要

In this review, our objective was to identify and compare the most commonly used organ preservation solutions and discuss results of studies with additives to these solutions and with experimental solutions. An integrative literature review was carried out by selecting relevant publications on preservation solutions used in organ transplant via electronic searches in PubMed, the Scientific Electronic Library, the Latin American and Caribbean Literature in Health Sciences, and MEDLINE databases. In total, 275 articles were collected, of which 52 papers were considered based on the inclusion criteria. Although there are established preservation solutions among medical transplant teams, such as Collins, University of Wisconsin, IGL-1, histidine tryptophan-ketoglutarate, and Celsior, these solutions still have functional limitations on protection against ischemia-reperfusion injury. Therefore, new substances and alternative methods of conservation have been researched. The present paper found several experimental solutions, additives, and micronutrients with great potential for preserving grafts and minimizing ischemia-reperfusion injury, emphasizing the importance of continued research into alternatives to standard solutions.