COVID-19 in children with chronic kidney disease: findings from the UK renal registry

摘要

As Munro and Faust point out, there appears a stark contrast in the case and mortality rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among children compared with the adult population.1 Whether infection in children is generally mild or asymptomatic, which goes undetected, or children are less susceptible to contracting the infection is unclear until screening programmes are introduced. What also remains uncertain is the risk of severe infection for children with significant underlying health concerns, including those with chronic kidney disease (CKD). The few studies reported have so far shown reassuringly low numbers and complication rates in children with coexisting diseases such as cancer and liver transplant recipients.2 3 The NHS England COVID-19 service evaluation (https://www.rcpch.ac.uk/resources/covid-19-service-evaluation-audit-care-needs-children-admitted-hospital-england), to date, has identified 220 confirmed cases in England of whom 44.4% of cases have coexisting disease; two children are reported to have CKD.