Editor profiles: Guest editors of special issue “The biological fate of drug nanocarriers”

摘要

The cover draws on the story of "Journey to the West"―the Flaming Mountain. The monk Tang and his disciples passed through the Flaming Mountain on their way to the West Heaven for Buddhist scriptures. The four of them were sweating, thirsty, and the ground dried up. The people were not harvested, and were starving to death everywhere. Fortunately, the monkey Wukong borrowed the palm-leaf fan and just fan it three times: one to turn off the fire, two to generate wind, and three to rain. When the people received rain, they all cried with joy and paid homage. In this study, we found that the active component celastrol improved the metabolic syndrome induced by high fat diet in mice through binding its target protein CAP1 to inhibit cAMP-PKA-NF-kB signaling pathway in macrophage. The cover story is just as it is said: celastrol (palm-leaf fan) targets CAP1 to inhibit (fan out) the inflammation (fire) on macrophages (Flaming Mountain) and ameliorates metabolic syndrome in mice.