Adding prostate-specific membrane antigen positron emission tomography (PSMA PET) to our prostate cancer armamentarium raises many questions

摘要

Prostate-specific membrane antigen positron emission tomography (PSMA PET) is a major advance in detecting recurrent prostate cancer and is increasingly used for prostate cancer diagnostics. PSMA is a transmembrane protein that provides an important target for radiolabeled imaging, since its expression is upregulated in malignant prostate cells, correlates with higher tumor grades, and is negatively regulated by androgen levels (increased expression with castration). According to these features, it is near ideal for detecting significant recurrences, both primary and in the castration-resistant state.