COMPETITIVE PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) BINDING AGENTS FOR THE REDUCTION OF NON-TARGET ORGAN UPTAKE OF RADIOLABELED PSMA INHIBITORS FOR PSMA POSITIVE TUMOR IMAGING AND RADIOPHARMACEUTICAL THERAPY

摘要

Methods for co-injection of a non-radioactive PSMA inhibitor, referred to herein as a competing inhibitor (CI), with a radiolabeled PSMA inhibitor are disclosed. This combination reduces the uptake of the radiotracer in non-target organs, including the kidneys and lacrimal glands, with only a modest reduction in tumor uptake.