The clinical diagnosis of seborrheic keratosis (SK) is still a challenge for dermatologists, although it is a common benign skin tumor.[1] Among all, pigmented and irritated types of SK may closely resemble malignant skin tumor-like basal cell carcinoma or melanoma. Recent treatments of SK include hydrogen peroxide, nitric–zinc complex, and ablative laser therapy, but cutaneous cryotherapy, a classical treatment, appears to be preferred presumably because of its convenience.[2] Without histological confirmation, these treatments sometimes modify the clinical appearance and make the diagnosis of SK more difficult. We report a case of cryotherapy-modified SK which was clinically diagnosed as malignant melanoma and totally excised with 5 mm surgical margin.
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