THERAPEUTICAL COMPOSITIONS FOR USE IN THE TREATMENT OF NON- MALIGNANT CONDITIONS ASSOCIATED WITH PHOSPHATIDYLINOSITOL-3- KINASE ACTIVATION: OVERGROWTH SPECTRUM, CUTANEOUS CAPILLARY MALFORMATIONS AND SEBORRHEIC KERATOSES

摘要

A pharmaceutical composition for use in the treatment of PIK3CA Related Overgrowth Spectrum, cutaneous capillary malformations, and seborrheic kératoses comprising an inhibitor of heat-shock factor 1 (HSF1 ), wherein the inhibitor of heat-shock factor 1 is selected among one or more of Triptolide, Minnelide, Kribb11, Quercetin, QC-12, Quercetin derivatives, KNK437, Stresgenin B, Emunin, NZ28, Cantharidin, Rocaglamide A, Rohinitib, Rohinitib-Cantharidin hybrids ligands, Arctigenin, and pharmaceutically acceptable derivatives, salts and solvates thereof.