Commentary: Coronavirus and Obesity: Could Insulin Resistance Mediate the Severity of Covid-19 Infection?

摘要

Insulin Resistance (IR) might be a potential key factor behind the COVID-19 severity foundin people with obesity. An article published on Frontiers Public Health supported the evidenceof possible mechanisms linking IR and COVID-19 severity via the upregulation of ACE 2, theprotein involved in virus entry (1). This research area is worthy of being investigated further forits implication in the prevention and treatment of this dramatic pandemic. We need to understandthe molecular mechanisms related to the higher risk both of being infected by SARS-CoV-2 and ofdeveloping a more severe disease (COVID-19).