Effect of microincisional cataract surgery on inflammatory indicators in tears and corneal endothelial cells in cataract patients

摘要

Objective: To analyze the effect of microincisional cataract surgery on inflammation in tears and corneal endothelial cells in cataract patients. Methods: A total of 103 patients with cataracts in our hospital were enrolled and randomly divided into group A (n=52) and group B (n=51) by a random double-blind lottery. Group A received 1.8 mm coaxial microincision cataract surgery (C-MICS) while group B received 3.0 mm C-MICS, and the efficacy was compared between the two groups. Results: Average ultrasound energy (AVG), accumulative phaco time (APT), and effective phaco time (EPT) did not differ between groups ( P 0.05). Group A exhibited higher interleukin-2 (IL-2) levels at 5 days postoperatively and lower interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), and tumor necrosis factor-β1 (TNF-β1) levels than group B ( P 0.05). Group A had higher visual acuity and lower visual acuity loss, visual fatigue, foreign body sensation, tingling, and photophobia scores than group B at 7, 14, and 28 days postoperatively ( P 0.05). The tear film break-up time (TBUT) in group A was longer than that in group B at 7, 14, and 28 days postoperatively, and the tear secretion length (in mm) on the strip in group A was longer than that in group B at 14 and 28 days postoperatively ( P 0.05). Conclusion: Compared with other types of similar surgery, C-MICS can significantly control inflammation levels, with less effect on corneal endothelial cells, improve postoperative visual acuity, delay tear film break-up, increase tear secretion, and improve dry eye syndrome.