Influence of Xuebijing injection combined with cefoperazone sodium and sulbactam sodium in treating hepatitis B-induced liver cirrhosis complicated by spontaneous bacterial peritonitis: TNF-α, IL-18, IL-6, and hepatic function

摘要

Objective: To analyze the influences of Xuebijing injection combined with cefoperazone sodium and sulbactam sodium (CSSS) in the treatment of hepatitis B-induced liver cirrhosis (HBLC) complicated by spontaneous bacterial peritonitis (SBP) with respect to tumor necrosis factor-α (TNF-α), interleukin-18 (IL-18), interleukin-6 (IL-6), and hepatic function. Methods: A total of 98 patients with HBLC complicated by SBP admitted to our hospital were selected and divided into the control group (CON, n=49) and the observation group (OBG, n=49) in accordance with the therapeutic methods. The clinical data of the patients were retrospectively analyzed. The CON was treated with CSSS, while the OBG was treated with Xuebijing injection combined with CSSS. The time of symptomatic improvement and changes of serum inflammatory factors and indices of intestinal mucosal barrier damage and hepatic function were compared between the two groups before and after treatment. Results: The time of symptomatic improvement in the OBG was shorter than that in the CON ( P 0.05). After treatment, IL-6, IL-18, TNF-α, urinary L/M, D-lactic acid, DAO, total bilirubin, ALT, and AST in the OBG were lower than those in the CON ( P 0.05). Conclusion: Xuebijing injection combined with CSSS is conducive to improving the inflammatory responses of the body, intestinal tract barrier function, and hepatic function, showing satisfactory efficacy in the treatment of HBLC complicated by SBP.