Effects of esketamine combined with ultrasound-guided nerve block on cognitive function in children with lower extremity fractures

摘要

Objective: To explore the effect and complications of esketamine combined with ultrasound-guided nerve block in children with lower extremity fractures. Methods: 120 children with fractures of lower extremities were included into the observation group (OG) and control group (CG) according to the specific anesthesia method. The OG was given esketamine combined with ultrasound-guided nerve block, and the CG was given ultrasound-guided nerve block combined with general anesthesia. Serum norepinephrine (NE), epinephrine (E), renin (R), mean arterial pressure (MAP), heart rate (HR), oxyhemoglobin saturation (SpO 2 ) and respiration rate (RR) were measured before, at 10, 20, and 30 min after anesthesia. The incidence of clinical complications and the anesthetic effects were compared between the two groups. The mini-mental state examination (MMES) scale was performed to evaluate the cognitive function of children in the two groups before and after surgery. Results: At 10 min and 20 min after anesthesia, the CG showed higher MAP and HR than the OG ( P 0.05). At 30 min after anesthesia, HR and MAP were not significantly different between the two groups ( P 0.05); NE, E, and R showed no significant difference before surgery ( P 0.05), which were higher in CG than those in the OG after surgery ( P 0.05). The OG had a complication rate of 8.33%, significantly lower than that of 20.00% in the CG ( P 0.05). Conclusion: Esketamine combined with ultrasound-guided nerve block anesthesia was superior to ultrasound-guided nerve block combined with general anesthesia in children with lower extremity fractures, with fewer compilations.