The effect of intra-articular injection of antibacterial drugs in the clinical treatment of prosthetic joint infection in patients undergoing artificial hip replacement

摘要

Objective: To study the clinical effect of intra-articular injection of antimicrobials in the treatment of prosthetic joint infection (PJI) in patients undergoing artificial hip replacement surgery and its impact on the quality of life. Methods: A retrospective analysis of the clinical data of 116 patients with PJI after artificial hip replacement in our hospital from June 2016 to June 2017 was performed, and they were randomly divided into a study group and a control group, with 58 in each group. The study group was treated with intra-articular injection of antibacterial drugs, and the control group was injected with sodium hyaluronate. The antibacterial effects of the two groups were compared. Results: The HHS scores of the two groups of patients after treatment increased (P 0.001), and the increase of the study group was more relevant (P 0.001). The IL-17 and IL-6 levels noticeably decreased (P 0.001), and the decrease in the study group was more significant (P 0.001). The total effective rate after 6 weeks of treatment in the study group was evidently higher compared with the control group (P 0.05). The quality of life scores of the two groups of patients after treatment increased (P 0.001), and the the study group was much better (P 0.001). Lower incidence of adverse reactions was identified in the study group (P 0.05). Conclusion: Intra-articular injection of antimicrobials can effectively improve the hip joint function of patients, reduce inflammation, improve the quality of life, and the incidence of adverse reactions is relatively low. It has high clinical application value and is worthy of use and promotion.