Bio-inert Properties of TEG Modified Dendrimer Interface

摘要

The bioinert interfaces that prevent adhesion of proteins and cells are important for biomaterial applications.In order to design a bioinert interface, the immobilization of an appropriate functional group and the control of molecular density is required.Dendrimer was modified with triethylene glycol (TEG) to display a dense brush structure.TEG with different density and terminal groups were immobilized with a dendrimer template and thiol terminated molecules.The inhibitory effect on protein and bacteria binding was investigated.The physical property of the interface was measured by QCM-admittance to clarify the factor of the bioinert property.