A SERIES OF MIXED LIGAND METAL COMPLEXES: SYNTHESIS, CHARACTERIZATION AND MOLECULAR DOCKING INVESTIGATIONS AGAINST CORONAVIRUS SPIKE PROTEIN

摘要

A series of mixed ligand complexes with a Schiff base (HL1) (obtained from 2-hydrazinobenzimidazole and ohydroxyacetophenone) acts as primary ligand and 1,10-phenanthroline (secondary ligand, L2) have been synthesized and investigated by various physico-analytical techniques.The spectral results suggested the tridentate nature of the Schiff base with NNO donor type.The prepared complexes exhibited distorted octahedral geometry.Moreover, molecular docking studies have been carried out against the SARS-CoV-2 spike receptor-binding domain (PDB ID: 6M0J) and SARS-CoV spike receptor-binding domain (PDB ID: 2AJF).