Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand.-Mazz

摘要

Sixteen diterpenoid alkaloids (DAs), including six aconitine-type alkaloids ( 5 and 9 ??? 13 ), seven 7,17- seco -aconitine-type alkaloids ( 1 ??? 4 , 6 ??? 8 ), two napelline-type alkaloids ( 14 and 15 ) as well as one veatchine-type alkaloid ( 16 ), were isolated from the aerial parts of Aconitum flavum Hand.-Mazz. In which, flavumolines A???D ( 1 ??? 4 ) were four new ones, and flavumoline E ( 5 ) was reported as natural compound for the first time. Their chemical structures were elucidated by the analysis of extensive spectroscopic data. The inhibitory activities of these isolates on Ca _(v)3.1 low voltage-gated Ca ~(2+) channel, NO production in LPS-activated RAW264.7cells, five human tumor cell lines, as well as acetylcholinesterase (AChE) were tested. Supplementary Information The online version contains supplementary material available at 10.1007/s13659-021-00302-3.