Hypersampsones S–W, new polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii

摘要

Five new polycyclic polyprenylated acylphloroglucinols ( 1–5 ) with a bicyclo[3.3.1]nonane skeleton, along with five known analogues ( 6–10 ), were isolated from the aerial parts of Hypericum sampsonii . Their structures, including the absolute configurations of 1–5 , were elucidated by spectroscopic analysis, modified Mosher's method, ECD calculations and in situ dimolybdenum CD method. Besides, all the compounds were evaluated for RXRα transcriptional-inhibitory activities and cytotoxicity against HeLa cells.