Zn-catalyzed hydrohydrazination of propargylamides with BocNHNH2: a novel entry into the 1,2,4-triazine core

Alexey Lukin; Tatiana Vedekhina; Dmitry Tovpeko; Nikolay Zhurilo; Mikhail Krasavin

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Zn-catalyzed hydrohydrazination of propargylamides with BocNHNH2: a novel entry into the 1,2,4-triazine core

机译：用BOCNHNH2 Zn催化的炔丙基丙氨酸氢化物：进入1,2,4-三嗪芯的新型进入

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Hydrohydrazination of a variety of propargylamides with BocNHNH _(2) under Zn(OTf) _(2) catalysis, unexpectedly, gave dihydro-1,2,4-triazines with a loss of the protecting group. The initial products can be efficiently aromatized in situ with K _(3) [Fe(CN) _(6) ]. This provides a new entry into the medicinally important 1,2,4-triazine core.

机译：在Zn（OTF）_（2）下用BOCNHNH _（2）在Zn（OTF）_（2）催化，意外地进行了多种丙氨酸的氢化氢化物，得到了保护基团的失去的二氢-1,2,4-三嗪。初始产品可以与K _（3）[Fe（CN）_（6）]原位有效地芳香化。这为药用的1,2,4-三嗪芯提供了新的进入。

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《RSC Advances》 |2016年第63期|共4页
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Alexey Lukin; Tatiana Vedekhina; Dmitry Tovpeko; Nikolay Zhurilo; Mikhail Krasavin;
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1. Zn-catalyzed hydrohydrazination of propargylamides with BocNHNH(2): a novel entry into the 1,2,4-triazine core [J] . Lukin Alexey, Vedekhina Tatiana, Tovpeko Dmitry, RSC Advances . 2016,第63期

机译：用BOCNHNH（2）Zn催化的丙氨酸丙氨酸氢化氢化物：进入1,2,4-三嗪核的新进入
2. A novel Zn-catalyzed hydroamination of propargylamides: a general synthesis of di- and tri-substituted imidazoles [J] . Anahit Pews-Davtyan, Matthias Beller Chemical Communications . 2011,第7期

机译：炔丙基酰胺的新型锌催化加氢胺化反应：二取代和三取代的咪唑的一般合成
3. 1,2,4-Triazines in organic synthesis. 37 - Transformations of Phenylhydrazones of 5-Acyl-1,2,4-triazines to Pyrazolo[4,3-e][1,2,4]triazines or 4-Cyanopyrazole [J] . Mojzych M, Rykowski A Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry . 2007,第5期

机译：1,2,4-三嗪在有机合成中。 37-5-酰基-1,2,4-三嗪的苯并nes转化为吡唑并[4,3-e] [1,2,4]三嗪或4-氰基吡唑
4. Molecular Structures, Rotational Barriers, and Density Functional Theory Studies on 3,5-Diamino-6-(2,3-Dichlorophenyl)-1,2,4-Triazine [C] . Pek-Lan Toh, Suh-Miin Wang International Conference on Computational Science and Engineering . 2019

机译：分子结构，旋转屏障和密度泛函理论研究3,5-二氨基-6-（2,3-二氯苯基）-1,2,4-三嗪
5. THE SYNTHESIS OF CERTAIN NOVEL AZINE "C"-NUCLEOSIDES (PYRIMIDINE, (1,2,4)TRIAZINE, S-TRIAZINE, C-GLYCOSYL AMIDINE, AMIDRAZONE). [D] . RILEY, TIMOTHY A. 1985

机译：某些新颖的叠氮“ C”-核苷（嘧啶，（1,2,4）三嗪，S-三嗪，C-糖基A啶，酰胺基）的合成。
6. 2-[(Cyclohex-3-en-1-ylmethoxy)methyl]-6-phenyl-1,2,4-triazine-3,5(2H,4H)-dione [O] . Nasser R. El-Brollosy, Mohamed I. Attia, Ali A. El-Emam, 2015

机译：2-[（环己基-3-en-1-基甲基氧基）甲基] -6-苯基-1,2,4-三嗪-3,5（2H，4H）-二酮
7. Synthesis and pharmacological evaluation of new fluorine substituted pyrimido1,2-b1,2,4triazines and 1,3,5-triazino-1,2-b1,2,4triazines derived as CDK2 potential inhibitors [O] . Dina Bakhotmah, Fatimah Alotaibi 2020

机译：新型氟取代嘧啶的合成和药理评价1,2- b 1,2,4三嗪和1,3,5 - 噻嗪 - 1,2,4三嗪衍生成CDK2潜在抑制剂
8. Preparation of as-triazine /1,2,4-triazine/ and related compounds progress report, period ending mar. 31, 1965 [R] . 1965

机译：制备三嗪/ 1,2,4-三嗪/及相关化合物的进展报告，截止日期为3月。 1965年31日

Zn-catalyzed hydrohydrazination of propargylamides with BocNHNH2: a novel entry into the 1,2,4-triazine core

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