Hydrogenation of crude and purified d-glucosone generated by enzymatic oxidation of d-glucose

摘要

D -Fructose is an important starting material for producing furfurals and other industrially important chemicals. While the base-catalyzed and enzymatic conversion of D -glucose to D -fructose is well known, the employed methods typically provide limited conversion. D -Glucosone can be obtained from D -glucose by enzymatic oxidation at the C2 position and, subsequently, selectively hydrogenated at C1 to form D -fructose. This work describes an investigation on the hydrogenation of D -glucosone, using both chromatographically purified and crude material obtained directly from the enzymatic oxidation, subjected to filtration and lyophilization only. High selectivities towards D -fructose were observed for both starting materials over a Ru/C catalyst. Hydrogenation of the crude D -glucosone was, however, inhibited by the impurities resulting from the enzymatic oxidation process. Catalyst deactivation was observed in the case of both starting materials.