Finely crafted quasi-core–shell gadolinium/layered double hydroxide hybrids for switching on/off bimodal CT/MRI contrasting nanodiagnostic platforms

摘要

We successfully synthesized a size-controlled hybrid of layered double hydroxide (LDH) platelets and Gd(OH) _(3) nanorods through the reverse micelle method. Under controlled synthetic conditions, the hybrid was developed to a quasi-core–shell structure, where the Gd(OH) _(3) nanorods were covered by the LDH platelet assembly, and this was investigated by X-ray diffraction and high-resolution transmission electron microscopy. The zeta potential measurement for the hybrid revealed that Gd(OH) _(3) was surrounded by LDH moieties. According to dynamic light scattering, the hydrodynamic radius of the hybrid was uniformly controlled under 150 nm, which was comparable to that of one Gd(OH) _(3) nanorod surrounded by an LDH moiety. Thus, the obtained hybrid exhibited a maximum Hounsfield unit of 180 at a concentration of 5 mg mL ~(?1) , implying its potential as a computed tomography contrast agent. The magnetic resonance relaxivities of the hybrid were examined at pH 5 and 7, simulating lysosomal and plasma conditions; the r _(1) values were 7.3 and 2.9, respectively, which were highly dependent on the physiological conditions.