Synthesis, Characterization, Photoluminescence, Molecular Docking and Bioactivity of Zinc (II) Compounds Based on Different Substituents

摘要

Six new zinc(II) complexes were prepared by the reaction of ZnBr 2 or ZnI 2with 4 0 -(substituted-phenyl)-2,2 0 :6 0 ,2 00 -terpyridine compounds, bearing p-methylsulfonyl (L 1 ),p-methoxy (L 2 ) and p-methyl (L 3 ), which were characterized by elemental analysis, FT-IR, NMR andsingle crystal X-ray diffraction. The antiproliferative properties against Eca-109, A549 and Bel-7402cell lines and the cytotoxicity test on RAW-264.7 of these compounds were monitored using a CCK-8assay, and the studies indicate that the complexes show higher antiproliferative activities thancisplatin. The interactions of these complexes with CT-DNA and proteins (BSA) were studied byUV-Vis, circular dichroism (CD) and fluorescent spectroscopy, respectively. The results indicatethat the interaction of these zinc(II) complexes with CT-DNA is achieved through intercalativebinding, and their strong binding affinity to BSA is fulfilled through a static quenching mechanism.The simulation of the complexes with the CT-DNA fragment and BSA was studied by using moleculardocking software. It further validates that the complexes interact with DNA through intercalativebinding mode and that they have a strong interaction with BSA.