Infertility: Plant Derived Bitter Tasting Compounds to Slack off the Bitterness of Genital Infections. Real or Just a Hype?

摘要

Infertility refers to the inability of a reproductiveaged woman (from 15 to 49 years old) to conceive after 12 months of sexually active life [1]. Globally, infertility affects about 80 million couples and is associated a huge psychosocial burden [2]. Both male and female factors comprising about 20–50% and 26-50% respectively contribute to development of infertility. Though multiple causes of infertility have been reported [3–5], genital infections continue to constitute the greatest risk for infertility, accounting for about 15–35% of infertility cases in males [5] and 50– 75% of infertility cases in females [4]. Despite substantial improvement in medical treatment, incidence of genital infections has continued to increase over the past years in addition to ever increasing microbial resistance experienced in clinical practice [1,5].