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首页> 外文期刊>Journal of Zhejiang University. Science, B >Using genetic markers in unpedigreed populations to detect a heritable trait
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Using genetic markers in unpedigreed populations to detect a heritable trait

机译:在不佳的人群中使用遗传标记来检测一个遗传性的特质

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Before a breeder invests selection pressure on a trait of interest, it needs to be established whether that trait is actually heritable. Some traits may not have been measured widely in pedigreed populations, for example, a disease or deformity may become more prevalent than previously, but is still relatively rare. One approach to detect inheritance would be to screen a commercial population to obtain a sample of “affecteds” (the test group) and to also obtain a random control group. These individuals are then genotyped with a set of genetic markers and the relationships between individuals within each group estimated. If the relatedness is higher in the test group than in the control group, this provides initial evidence for the trait being heritable. A power simulation shows that this approach is feasible with moderate resources.
机译:在育种者对感兴趣的特征投资选择压力之前,需要确定该特质是否实际上是可遗传的。在侏儒群中可能没有广泛衡量一些特征,例如,疾病或畸形可能比以前更普遍,但仍然比较少见。检测遗传的一种方法是筛选商业人群以获得“受影响”(测试组)的样品,也可以获得随机对照组。然后将这些个体与一组遗传标记进行基因分型和每个估计的每个组内的个体之间的关系。如果测试组中的相关性比对照组更高,那么这为特性提供了可遗产的初始证据。功率仿真表明,这种方法是可行的,具有中等资源。

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