Antiulcerogenic effects of Celosia trigyna plant extracts on ethanol-induced gastric ulcer in adult Wistar rats

摘要

Background and aimGastric ulcer is a chronic disease and serious health issue.Celosia trigynais a medicinal plant used traditionally for wound healing. This study aimed to isolate the bioactive compounds fromCelosia trigynaand to investigate thein?vitroandin?vivoanti-ulcerogenic effects of the extractson ethanol-induced gastric ulcer on adult Wistar rats to determine their regenerative potential.Experimental procedureSeven groups (A – negative control, B – vehicle control, C, D, E, F and G – positive control, n?=?5) of five adult Wistar rats received treatment for ethanol-induced gastric ulcer.Results and conclusionPhytochemical analysis led to the isolation of chondrillasterol, lutein, pheophytin a and chondrillasterol acetate. Thein?vitroresults showed dichloromethane and hexane extracts to have maximum chymotrypsin inhibition relative to the standard (chymostatin) whilein?vivoresults showed a significant increase in ulcer parameters of the vehicle control relative to groups treated with plant extracts (P?