Is a monovalent vaccine against enterovirus 71 sufficient? A review of enterovirus 71 vaccine development based on enterovirus surveillance in Taiwan

摘要

Non-polio enteroviruses are among the most common viral infectious agents. More than 60 serotypes of enteroviruses are classified into four groups: coxsackievirus A (CA), cox- sackievirus B (CB), echovirus (Echo), poliovirus and new enterovirus. While most enteroviral cases are either asymptomatic or have mild symptoms (e.g., mild upper respiratory problems), some cases exhibit symptoms such as hand-foot-mouth disease (HFMD), herpangina, aseptic encephalitis, viral meningitis and acute hemorrhagic conjunctivitis. Severe complications have potentially lethal consequences.