Promoting osteoblasts responses in vitro and improving osteointegration in vivo through bioactive coating of nanosilicon nitride on polyetheretherketone

摘要

ObjectiveTo enhance the bioactivity of polyetheretherketone (PEEK) while maintain its mechanical strengths.MethodsSuspension coating and melt bonding.ResultsSilicon nitride (Si3N4, SN) coating lead to higher surface roughness, hydrophilicity and protein absorption; SN coating could slowly release Si ion into simulated body fluid (SBF), which caused weak alkaline of micro-environment owing to the slight dissolution of SN; SN coating resulted in the improvements of adhesion, proliferation, differentiation and gene expressions of MC3T3-E1 cellsin vitro; SN coating of PEEK with bioactive SN coating (CSNPK) obviously promoted bone regeneration and osseointegrationin vivo.ConclusionsCSNPK with SN coating as bone implant might be a promising candidate for orthopedic implants.The Translational Potential of this ArticleThe silicon nitride-coated polyetheretherketone (CSNPK) prepared in this article could induce MC3T3-E1 cells adhesion, proliferation and differentiationin vitro; it could also induce bone regeneration in bone defectin vivo, which indicate its good cytocompatibility and biocompatibility. If the raw materials are medical grade, and preparation process as well as production process of this article are further improved, it will have great translational potential.