Celery ameliorating against neurobehavioral and neurochemical disorders of perinatal lipopolysaccharides exposure in mice offspring

摘要

In this study, the role of Lipopolysaccharide (LPS) on the neurochemical disruption and neurobehavioural changes in offspring of mice was analyzed. Totally 30 pregnant mice was selected and divided in to six groups.Apium graveolenswas supplemented at various doses to the experimental animals. This experiment was started at the day of pregnancy and was continued up to post-natal day 15. In our experiment three pups from each set of experiment were carefully marked and analyzed its physical, biochemical and behavioral changes. The experimental animals showed decreased body weight, delayed eye opening and delayed hair growth. Also, LPS treated pups showed cliff avoidance and rotating reflexes. Pups exposed to LPS showed heavy learning deficits and memory loss. In the treated pups, decreased level of dopamine, acetylcholinesterase and serotonin in forebrain was observed than celery groups. The present finding showed that the treatment of Celery revealed potent activity on behavior and biochemical disorders. Administration of celery enhanced cognition behavior in experimental animals.