The effect of vitamin K on the wound healing process in rat skin achieved by common wound dressing agents

摘要

Background and objective: Vitamin K is a fat-soluble vitamin that plays an important rolein the coagulation pathways of living organisms. A popular application of vitamin K hasbeen used to help in the extravascular removal of blood from the skin. The aim of thepresent study was to test the wound healing effect of vitamin K and some common wounddressing agents available in Erbil city clinical settings such; the moist exposed burnointment (MEBO) and the Cica silver spray to test their combination with vitamin Kinjections.Methods: Six groups of albino rats were used (6 rats in each group). Group M receivedMebo ointment, Group Creceived Cica silver spray, Group K received Vitamin K injection,Group MK received Mebo ointment+vitamin K injection.Group CK received Cica silverspray +vitamin K Group, and Group N received no- treatment. The duration of theexperiments was as 7, 14, and 21 days post wound surgery.The percentage of woundcontraction was measured, and the blood serum was collected to test the level oftransforming growth factor β (TGFβ) and platelet-derived growth factor (PDGF).Results: Data presented in our study showed that the best wound contraction percentage(99%) was obtained by the MK treated rats compared to the control group. Similar resultswere obtained fromTGFβ and PDGF data in which MK group showed a significant increasein the levels of these growth factors.Conclusion: The wound healing process is supposed to be due to an increase of TGFβ,PDGF, and enhanced fibroblast proliferation and neovascularization of tissues.