Atrophic glossitis in pernicious anemia patients can be treated to normal in two weeks by intramuscular injection of vitamin B12

摘要

PA is a type of macrocytic anemia. Macrocytic anemias are generally classified into megaloblastic or non- megaloblastic anemia. Megaloblastic anemia is caused by deficiency or impaired utilization of vitamin B12 and/or folic acid, whereas nonmegaloblastic macrocytic anemia is caused by various diseases such as myelodysplastic syn- drome, liver dysfunction, alcoholism, hypothyroidism, and certain drugs. Vitamin B12 deficiency is the most common cause of megaloblastic anemia and is caused by insufficient dietary intake, malabsorption due to the absence of intrinsic factor caused by PA or following gastric surgery, or transcobalamin II deficiency.’ Folic acid deficiency is caused by nutritional deficiency, malabsorption, increased requirements, or medication (e.g., methotrexate, trimethoprim, phenytoin).' Patients with myelodysplastic syndrome may present with pancytopenia including ane- mia, thrombocytopenia, and neutropenia. ' Alcoholism is a well-known cause of macrocytic anemia, because chronic consumption of more than 80g of alcohol per day has adverse effects on the hematologic system.