177Lutetium SPECT/CT: Evaluation of collimator, photopeak and scatter correction

摘要

Purpose The goal of this study was to find the optimal combination of collimator, photopeak and scatter correction for 177Lutetium (177Lu) SPECT/CT imaging. Methods Three experiments [sphere‐to‐background ratios (SBR) 50:1, 10:1, and 2:1] were performed with the NEMA Image Quality phantom filled with 177Lu‐trichloride. SPECT/CT acquisitions were performed with the medium‐energy low‐penetration (MELP) collimator and 99m?5), whereas the MELP collimator showed a higher CNR for the 2:1 ratio. The RCmean was higher with the MELP collimator, most explicit after the 208‐keV AC/SC reconstruction for all acquisitions. The line profiles showed a better spatial resolution for the MELP collimator and the 208‐keV AC/SC reconstructions. Conclusion 177Lu SPECT/CT image quality and quantification was most optimal when acquired with the MELP collimator and reconstructed using the 208‐keV photopeak, with AC and SC.